What is pKa ? This may be something that people encounter for the first time and they do not know the answer to this question immediately. If you have always been fascinated with Science then you may already be aware of w hat is pKa. This is used in order to show the acidity level of certain acids, particularly weak acids. Usually, the value of the pKa may vary. The lower the pKa value is, the stronger the value of the acid is. This also means that the higher the pKa value is, the stronger and more stable the conjugate base is. There are different acids and bases in this world, stronger acids will always remain constant but there are a lot of weak acids that can change in form.
Ka is known as acid disassociation constant. This means that it measures the strength of the acid in the whole solution. More often than not, the Ka is written in quotients of equilibrium concentrations. It can always be evident that the acid is weak if it has a value of -2 - 12, but if the value is -2 and below, the acid can be considered as a strong acid. For those who do not understand what equilibrium is, it is the state wherein the forward and reverse reactions are the same.
The importance of pKa is not often stressed in most books and even some articles, but they are actually considered to be the basis of how the reactions are going to be. Through pKa, people can already formulate what things are going to happen next with the compounds and groups in chemistry but it seems that because people do not understand what it means, and they do not ask what is pKa, they tend to disregard it. Some may think that pH is worth studying more, but is pKa considered to be unimportant? This is not true at all. There are a lot of chemists who make use of pKa all the time but since this is a concept that people do not know much about, they are not always as widely discussed as pH
So what is pKa then? The pKa is actually very important in organic chemistry and this is something that everyone should know about but there are always some who get confused with the difference between the pKa and pH. This will be discussed further later on. When it comes to pKa, the most important thing to remember is that the alkyl anions may be very important because they are the ones that can get the most protons and therefore can help anyone understand what the next reactions are going to be.
There is actually a pKa table that is being used in order to see what groups are strong and what groups would need to be stabilized so that they will not be weak anymore. Familiarizing with the various groups and what they can offer is very important because otherwise, nothing good will come out of the things that will be written about w hat is pKa in general. List of the commonly used pKa tables may be available in books and in some online websites. Complete lists may only be given to those who have access to it. For people who need it, they may have to request for it first.
Basically, it should be understood that pKa is different from pH. In pH, the amount of Hydrogen ions that are present in one solution or group is stated wherein pKa can offer the disassociation of the acid from the whole compound. The pKa is always expected to be constant and equal to the constant because like mentioned earlier, it is in equilibrium with the rest of the compounds. pH on the other hand, is dependent on the concentration of the compound that will be used so it can change. Both pH and pKa are considered to be highly important in understanding the behavior of chemicals that are being used in laboratories. One of the things that would have to be said about pKa is that it can still be influenced by other factors. Most people know w hat is pKa to be always constant but there are times when it can be influenced by temperature, ionic strength and the solvent dielectric constant. If the pKa will be exposed to these factors, the reactions may change.
The various approaches for knowing w hat is pKa may not be widely understood especially by people who are more interested in creating an english paper instead of something that is totally unrelated to science, but there will still be instances when pKa would need to be learned and while it may be forgotten after some time, its importance can be carried off and used in some things that are done every day.
There is a big chance that out of all the things that have been said about the pKa, most people still have questions that they just do not know how to answer. The most prominent one may be why is there a need for pKa. Why should people learn about pKa anyway? Without pKa, it will be impossible for some medications to be created. It is obvious that medications are needed in order to cure people. Without medications, people could have already succumbed to various diseases because there is no cure available. Mankind will be wiped out of the face of the earth very easily.
For some who realize the importance of pKa, they actually start doing a report about it the moment that they find out how to start a thesis usually with the help of their professors or teachers. For those who are wondering what is thesis, perhaps you are not yet of age to know how to make it but this is something that will be learned in the proper time. What is pKa can be answered immediately but how it can be used for everyday life may be something that people will not know urgently.
There are over 500 medications that have been created with the help of pKa and it is obvious that the numbers will keep on improving in the years to come. Usually, those who are in the pharmaceutical industry take note of how the various functional groups can react with other compounds. Based on this, how often the compounds occur will determine how effective it would be for certain conditions that are being targeted by the medications being made. The nature of the compounds can also determine how effective it is going to be when mixed with other acids or bases used in laboratories.
Another thing that has been improved by pKa is figuring out what are the strong acids and what are the strong bases that are currently available. Although there are a lot of acids and bases that are being compared, the strong ones are actually a bit short. You can expect that the following are strong acids and will not disassociate: HBr, HI, HNO3, HCIO4, HCl. If there are some acids that will be encountered in the future, these will most likely be weak acids that can easily disassociate in order to be mixed with other compounds.The number of strong bases is not that many as well. This means that all of the other acids and bases that are not considered strong can be changed as they can disassociate
Now that the things that it can do to modern medicine are discussed, it will be important to tackle the history of pKa. This is because the history of pKa may not be well known to a lot of individuals. Instead of asking what is pKa, perhaps now is the time to know how it started out. It has been said that it may have first been discovered by Guldberg and Waage in the year 1864. This may be the time when various measures have been done until they realized the degree of disassociation with the help of Van’t Hoff and Ostwald for things that are related to osmosis.
After a decade, Henderson published a paper stating the first measurement that was used before for pKa. He has proposed the differences between pKa, Ka, and pH. It seemed in the beginning that the first measurement is vital but it was changed in the year 1916 by Hasselback. The equation is known now as Henderson - Hasselback equation because they have both contributed to the creation of this equation. Although there may be other equations that are used in order to compute w hat is pKa, this may be the most common one used and this will be the method that will be taught to students as well.
A research summary of all things that will be learned about pKa are important because through the summary, you will get to have an overview of the things that you should learn about the important concept in organic chemistry. Even those who do not plan on working in the pharmaceutical industry may still have to go through this. So while this is being learned, it will be best to make the most out of it instead of becoming stressed over trying to understand what is pKa without actually doing any research about it. Writing a dissertation methodology regarding this topic may also help a lot. It is important to tackle all of the points that are needed when it comes to writing papers about pKa and of course, a brief background on how the whole concept was started can be of big help to a lot of individuals. For people who have an understanding of what pKa is, it will not be too much trouble to give information on what is pKa to others who may need to know more about it.