Student’s name Instructor’s name Course Date Testing in Advance for Genetic Diseases Discuss and Explain the main thesis of the Chapter.(E-text to perephrase) The main thesis of the chapter is whether it is important for people to test in advance for genetic disorders. It does this by examining whether it is good for individuals to undergo advanced testing for genetic diseases it also examines whether it is possible for people who are at risk to avoid genetic disorders. Although it is difficult to change an individual’s genetic make up testing in advance for genetic diseases can help one in reducing developing health problems. For instance Jolie the movie star after realizing that their family had genes of an individual to make independent and informed decisions on who and how others such as employers education institutions and insurers may know the results of their genomes. Confidentiality is another important ethical issue when it comes to gene testing. It implies that body information is sensitive and therefore accessing it must be controlled and limited to specific parties. Works Cited New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services. "Understanding Genetics: a New York Mid-Atlantic Guide for Patients and Health Professionals. Washington (DC): Genetic Alliance; 2012 Jul 8. APPENDIX Q National Coalition for Health Professional Education in Genetics (NCHPEG): Principles of Genetics for Health Professionals." GENETIC COUNSELING. Available from: www. ncbi. nlm. nih. gov 115552. [...]
INSTRUCTIONS – READ CAREFULLY Once you have reviewed the eText and all other Required Resources, answer each of the four parts of the assignment in IN YOUR OWN WORDS. Each of the four response should be a minimum of 150 words (not including citations) and in paragraph/essay format (no lists or bullet points). Your opinions and personal reflections should NOT be included in your responses. In most cases GHA answers will involve outside research (cited) to fully develop your response. Information from the eText and Required Resources are a starting point that must be built upon and developed with outside resources as you construct your response. The eText page numbers should be cited when necessary and all outside resources should be fully cited. Failure to cite resources or not putting responses into your own words will result in a zero for the entire assignment and a report of violation of academic integrity. All responses are submitted in SAFEASSIGN. YOU MUST CHECK OFF THE PLAGIARISM BOX WHEN SUBMITTING or you will receive a 1-point deduction. 1. Discuss and Explain the main thesis of the Chapter.(E-text to perephrase) 2. Discuss and Explain the main thesis that unites all three videos together under one central theme. 3. Discuss and Explain the phrase “quality of life” specifically in regards to advance testing for genetic diseases. 4. Discuss and Explain the possible ethical outcomes (Both pro and con) of advance testing for genetic diseases. REQUIRED RESOURCES: Readings, Website Reviews, Video Clips eText: Chapter 16 Videos: 1. CNN - Designer Babies (8 minutes) www.youtube.com 2. Genetic Disorders and Diseases (9 minutes) www.youtube.com 3. Genetic Testing in the 21st Century (35 minutes) www.youtube.com chapter 16- e-text paraphrase This chapter discusses two large themes: (1) is it wise to test in advance for genetic disease, and (2) can at-risk people do anything to avoid genetic diseases? The chapter focuses on two strong women, Angelina Jolie and Nancy Wexler, and their decisions to take or not take such presymptomatic tests. It discusses such testing for Huntington’s disease, breast and ovarian cancer, Type 2 diabetes, and Alzheimer’s disease. movie star Angelina Jolie wrote of a personal medical decision in an op-ed essay in the New York Times. 1 For a decade, her mother, Marcheline Bertrand, had fought both breast and ovarian cancer and died of it at age 56. Bertrand’s own mother had died of ovarian cancer at age 45. Jolie paid $3,000 for presymptomatic tests for analysis of BRCA1 and BRCA2 genes, which have lethal variants that carry an 87 percent risk of breast cancer and a 40 percent risk of ovarian cancer. Her tests came back positive for the bad variant or, as she put it, the “faulty” gene. Given how her mother died, and given her results, Jolie decided at age 37 to have a preventive double mastectomy. Three months after the private operation, she went public and caused a sensation. Actor Brad Pitt, her partner, supported She wrote that, after the mastectomy, her risk of developing breast cancer had dropped from 87 percent to under 5 percent. In 1990, Mary Claire-King discovered a mutation in a single gene, BRCA1 (BReast CAncer1) causing one form of breast cancer and ovarian cancer. In 1995, Alan Ashworth discovered another variant in another gene, BRCA2. In 2002, researchers discovered a third gene, CHEK2. Mutations in any of these genes can cause breast cancer. CASE 2: NANCY WEXLER AND HUNTINGTON’S DISEASE After a 10-year deterioration and catatonia, clinical psychologist Nancy Wexler’s mother died of Huntington’s disease, a fatal neurodegenerative disease. Because the Huntington’s gene is dominant, Nancy and her sister Alice each had a 50 percent risk of inheriting the disease. Because the average age of onset is 36, victims often have children before learning they are affected. By then, Nancy Wexler had become even more convinced that people should not take the test. In 2008, at age 63, she led the successful fight to get the FDA to approve tetrabenazine, the first drug that can ameliorate Huntington’s symptoms. 5 In 2013, at age 68, she still actively speaks on Huntington’s and presumably did not inherit the gene.