Student’s Name Instructor’s Name Course Date Genes and Cancer Oncogene is a gene that alternates impacting to cancer whereby; it changes from its normal functioning due to simple point of mutation in the gene sequence. Oncogenes are tumor-suppressors as well as microRNA DNA. The fluctuation on the DNA is unusual events though; the mutation can lead an individual to a heritable situation. In cell division Oncogenes are responsible for cell growth as well as inhabitation of apoptosis. The cancer DNA aids in compartment growth out of control thereby; creating a bridge of communication with a plasma membrane between the extracellular surrounding inside of the cell. The connection generates a signal that enzymatic activities online]. February 2014;122(2):193-200. Available from: GreenFILE Ipswich MA. Accessed July 29 2017. Levine A Puzio-Kuter A. The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes. Science [serial online]. December 3 2010;330(6009):1340-1344. Available from: Professional Development Collection Ipswich MA. Accessed July 29 2017. Polinsky Katherine R. Tumor Suppressor Genes. New York: Nova Biomedical Books 2007.Popat Uday R. Leukemia. New York NY: Demos Medical Pub 2011. Qi L Ding Y. Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer. Biomed Research International [serial online]. April 4 2017;:1-7. Available from: Academic Search Premier Ipswich MA. Accessed July 29 2017. The American Cancer Society. Oncogenes and Tumor Suppressor Genes. Medical Review. June 25 2014. [...]
Objectives: Develop your understanding of the factors controlling the cell cycle by learning about a specific cancer. Review/learn the role of oncogenes (chpt 14) in controlling the rate of cell division. Review/learn the roles of tumor –suppressing genes and apoptosis in preventing the accumulation and proliferation of cells with mutations. Alignment: This discussion board is designed to accompany the materials in Chapters 13, 14, and 15 (weeks 11, 12, and 13), and build on the materials in Chapter 14 on cancer and the cell cycle. You will be using internet resources to develop your understanding of the role of oncogenes, tumor suppressor genes, and apoptosis and then applying that understanding to understanding a specific cancer. Background: Essentially, cancer is a disease of cell division and has touched all of us in some way. I lost two grandparents to cancer and my mother is dealing with recurring (but thankfully non-metastatic!) cancer. In this discussion, we have an opportunity to explore cancer in more detail. Since cancer requires talking about genes and the complexities of cell division, it can be a little intimidating at first. However, there are many great resources on the internet. I will list a couple of my favorites below: For learning about oncogenes, tumor suppressors, and apoptosis: www.nature.com www.cancer.org For learning about specific genes involved in a specific cancer: The Genetics Home Reference -- ghr.nlm.nih.gov (I LOVE this resource and have used it a lot!) Don’t feel limited by my list. Feel free to find your own resources as well! Procedure: Use the materials in your textbook or from online sources to learn/review oncogenes. Summarize the role of oncogenes in controlling cell division. Use the materials in your textbook or from online sources to learn/review tumor suppressors and apoptosis. Summarize the roles of tumor suppressors and apoptosis in preventing mutations. Use online resources to investigate a specific cancer and find out two specific genes that are associated with the cancer. Use your resources to explain the role that these genes play. For instance, I could do a Google search or search on the Genetics Home Reference on “breast cancer genetics.” One of the genes that I’d find would be BRCA1. When I look up BRCA1 on the Genetics Home Reference webpage, I can find information about how BRCA1 works as a tumor suppressor with specific details that I could use for my discussion.