Enzymes increases the rates of chemical reactions by providing a reaction pathway with a changeover talk about free energy hurdle lower than the uncatalyzed response (i. e. by minimizing the free energy hurdle that separates the reactants and products). The diagram below shows the response coordinate. (a) Enzymes catalyzed oxidation-reduction reactions only in romantic relationship with small cofactors, which act like their chemical tooth. Cofactors may be ions like Cu2, Fe3+ or Zn2. The fundamental of cofactors determine why organisms only require track amount of certain elements in their diets. Cofactors may also be organic and natural molecules known as coenzymes. Cofactors are only temporary affiliates with the given enzyme molecules to function like cosubstrates.