Get help with any kind of project - from a high school essay to a PhD dissertation
Hygroscopicity in Pharmaceutics During formulation of existing and new drugs in pharmaceutics, hygroscopicity is among the important physiological parameters which can be studied in order to enhance the efficacy, stability and handling of this drug. Hygroscopicity has always been a significant aspect in pharmaceutics as the majority of the drugs either in tablet or alternative form is normally hygroscopic. Up to now, there remains no universally recognized definition of hygroscopicity because it is pushed by both thermodynamic and kinetic forces. Hygroscopicity can signify the amount of moisture absorbed or adsorbed by means of a substance from the air in addition to the rate of moisture uptake of a substance that is in a known relative humidity (Hilfiker, 2006, p. 236). A solid that can easily absorb moisture when exposed to the atmosphere of a famous relative humidity is said to be hygroscopic while the ability to absorb or adsorb moisture is popularly referred to as hygroscopy. Hygroscopy is known to happen either during absorption, adsorption or deliquescence in which the adsorbing or swallowing substance changes physically or chemically in most of its physicochemical attributes. Due to the adverse effects that it has on the end goods, highly hygroscopic medications will typically give weight changes which lead to tablets or film-coat breaking (Wermuth, 2008, p. 758). This has led to growth of formulations under controlled, humid conditions and expensive packaging are needed. This has pushed many companies to produce regulations and rules covering hygroscopicity. The medication ingredients used in drug manufacture are often aqueous salts which are prepared using strongly acidic or basic hydroxy-acids capsules and counter ions, which have a h.. .