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Introduction From the 16th century, the rumors of this Fountain of Youth had spread like wildfire. The idea of immortality, and everlasting childhood had fascinated many older, and young adventurers. Most Eukaryotic organism cells have been influenced by a biological process known as aging. Effect of aging could incorporate the arrival of illness, disease, and premature death. Death, this panic of conclusion existence had enthralled many people about the quest for prolonged endurance. Therefore, how do we expand our life span? Where is this "Fountain of Youth" ? Even though the latter question could forever remain a lucrative theory. Perhaps the answer to prolonged durability could live to a little known region of a chromosomes, the telomeres. By utilizing, and, if possible, changing this distinctive DNA structure, an individual may observe a reduction of age related illness, ailments, and signs of aging. In this review of human telomere, we will explore the roles and functions of the telomere, its arrangement, and the connection of telomere length to aging and tumorigenesis. Function and Function of this Telomeres Telomere are unique DNA structure that consist of repetitive nucleotide sequences, which serves as a "cap" to safeguard the ends of their chromosomes. These repetitive sequences can range from thousands of base pairs in Vertebrates to approximately several hundreds of base pairs from reproductive tissues (Oeseburg, et al. 2009). Situated at the ends of their chromosomes, the telomeres functions as a biological lifestyle line for cells. Once the telomeres reach a certain length, the cell will stop to divide. Oeseburg, et al (2009) implied that the telomere contains a crucial length, once attained, it might lead to chromosome end-to-end combination and chromosome malfunction; that may eventually lead to cell apoptosis, c.. .