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Alzheimer and Down's Syndrome Straight down?s Syndrome, Trisomy 21, or Mongolism is among the most typical factors behind mental retardation. Nearly all Down?s Syndrome sufferers possess a moderate retardation though it can range from slight to severe. Trisomy 21 occurs in about 1 in 800 live births. This incidence raises markedly as age the mother raises over 35. The prevalence in children born to young mothers is 1 in 1000, although it increases to almost 1 in 40 in children born to mothers over 40. Most people with Down?s Syndrome have got characteristic features such as for example upward slanted eyes, wide flattened face, short throat, and a prominent tongue. Muscle mass coordination is usually impaired in they, leading to uncoordinated balance and position. Congenital heart disease is situated in forty percent of the individuals, plus a near twenty fold upsurge in the chance of kidney malformation, thyroid abnormalities, diabetes, leukemia. Neurological retardation and impaired immune systems render they more vunerable to disease and infection. In the first l900s, Downs Syndrome patients lived to attain age twenty rarely, because they only had a life span of about 10 years. With the advances of modern healthcare, most individuals, excluding people that have irreparable heart damage, live to attain adulthood. Though it continues to be shorter than normal adults, their life span has risen to about fifty-five. The disorder was at first described as Mongolism by British physician John Langdon Down. Many theories for the etiology of the condition surfaced, including racial regression, endocrine gland dysfunction, and uterine exhaustion. It had been not before 1930s that Adrian Bleyer hypothesized tha...