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The Association Between Austism Spectrum and the Y Chromosome Essay

Project id 1001376
Subject area Biology
Document type Essay
Words 1837
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Due Date: Monday, the 5th of May 2014 THE ASSOCIATION BETWEEN AUTISM SPECTRUM DISORDERS AND Y CHROMOSOME -- A GENETICS LITERATURE REVIEW Introduction Autism appears at embryonic time and proceeds to get a life time of an individual. Signs of autism spectrum disorders (ASD) are the weakness in communication, perceptual disease, mental deficiency, tendency to isolate themselves in different individuals and repetitive behaviours. Obvious evidence was achieved from many preceding genetic studies that hereditary factors have a major influence on the autism ailments. However, the genetics of this ASD is so complex that it comprises mutations found in a number of loci as well as connections between multiple genes.1 In previous studies, many distinct genes (50 to 100 specific genes along with 20 to 40 chromosomal loci) associated with ASD were analyzed.2 The gene deletion mutations, amino acid substitutions, loss-of-function and gain-of function mutations may result in autism spectrum disorders. In addition, ASD is often related to mutations in sex chromosomes. Based on literature, the consequences of X chromosome mutations on ASD were largely focused on by the authors of previous reports that were published because the abnormalities between Y chromosome mutations were recognized from the genotype of dementia sufferers. But, recent research suggested that Y chromosome abnormalities play also a substantial part for ASD. In this literature review, the relation between XYY syndrome along with ASD was clarified so as to ascertain the association between Y chromosome abnormalities and ASD. The Effects of Neuroligin Coding Genes on ASD Recent studies indicated that neuroligin coding genes, including neuroligin-3 along with neuroligin-4 are connected with ASD. Some s.. .

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