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Sex Determining Region Y In mammals, both the X and Y-chromosomes decide the sex of an organism. If a mammal is homologous XX than this mammal is going to be female and if the mammal is heterozygous XY that person will be man, presuming no mutations. What's it about the Y chromosome that dictates the male sex? On the brief arm of the Y-chromosome is a area called the sex-determining region Y or SRY that codes for transcription factor "sex-determining Y" protein in mammals. Back in 1991, the role of SRY was demonstrated to be the sex-determining receptor in mice that was accountable for testes formation. This was determined in a study in which homologous XX mice (female) had been introduced to SRY and subsequently became male (Koopman et al. 1991). SRY is part of their SOX transcription factor family. Like many others in its own loved ones, SRY includes a high mobility group or HMG DNA-binding domain which is about eighty amino acids long that is structurally linked to other domains from the SOX household. The domain has a specific binding arrangement, AACAAAG or AACAAT, which is binds to some specific angle it bends at as it evolves to the particular sequence, where both the arrangement and the bending angle are crucial for function (Harley and Goodfellow 1994). In human females which are XY, many possess mutations in the HMG domain, again supporting the significance of the domain sequence for purpose and if SRY isn't expressed, genes extract female-specific traits and cause ovarian development. (Harley and Goodfellow 1994).) One of animal species SRY, aside from the HMG domain isn't highly conserved and varies between species. Many studies between SRY have used the mouse as a model. In an XY mouse embryo at 10 days post coitum or dpc, gonads arise from the genital ri...