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Septic Shock: Acute Generalised Exanthematous Pustulosis

An illusion of Septic Surprise: Acute Generalised Exanthematous Pustulosis with Multi organ Dysfunction

Acute Generalised Exanthematous Pustulosis (AGEP) is a uncommon cutaneous eruption, frequently caused by popular antibiotics. It really is seen as a an acute starting point of non-follicular sterile pustular rash and erythema within time or times of drug vulnerability and usually resolves spontaneously within 1-2 weeks once the drug is discontinued. Hemodynamic engagement in the form of shock is rare. Here, we present a serious case of AGEP, manifesting with systemic participation and hemodynamic instability resulting into great shock with multi-organ dysfunction. The associated drugs were Erythromycin and Fluconazole with a possible blended effect of both of these drugs that resulted in systemic participation. Our patient improved markedly, both his hemodynamically and dermatologically, after discontinuation of the drugs and with systemic steroid remedy.

BACKGROUND Why you think this circumstance is important - why have you write it up?

Acute Generalised Exanthematous Pustulosis (AGEP) is a exceptional condition which reveals with rapid onset of several non-follicular sterile pustules developing diffusely with an edematous and erythematous qualifications (1) (2). Systemic manifestations are typically limited to fever and leukocytosis. Reversible light hepatic and kidney injury have been reported occasionally (1) (3). AGEP is induced by drugs in 90% of the cases (3) and spontaneously resolves quickly after the offending agent has been discontinued. Topical ointment steroids are used for symptom alleviation and systemic steroids have been used in atypical severe presentations with systemic engagement (4) (5). Here we summarize a unique case of Erythromycin and Fluconazole induced severe form of AGEP presenting with shock requiring vasopressors and multi-organ dysfunction requiring CVVHD. Despite quick discontinuation of the offending agent, patient's condition prolonged to deteriorate until systemic steroids were initiated.

CASE Display Presenting features, medical/public/family history

A 61-year-old man with morbid weight problems, COPD, hypertension, and Type 2 diabetes mellitus was accepted to the hospital for acute starting point rapidly progressive diffusely erythematous allergy within the profound folds of his pannus and scrotum, which was refractory to over-the-counter topical therapy. There is concern for erythrasma so he was began on erythromycin and fluconazole. Within three times, the patient's rash spread diffusely across his trunk and extremities to create erythematous morbilliform papules which coalesced to form plaques. Within 12 time of noticeably worsening rash, the patient acutely decompensated, became short of breath and developed metabolic and breathing acidosis, requiring transfer to the Intensive Good care Product. He was in the beginning started on BiPAP, however anticipated to increasing somnolence he was intubated. He was known to be hypotensive with blood pressure of 66/42 mmHg, not attentive to intravenous liquid resuscitation. Patient was began on vasopressor support with norepinephrine. On lab examination, he was found to have leukocytosis (WBC 31. 10 10^3/uL), a mixed metabolic and breathing acidosis, lactic acidosis, as well as hepatic personal injury with AST of 4902 devices/ml and an ALT of 3073 models/ml. He eventually developed severe renal failure with a creatinine of 3. 06 mg/dL, hyperkalemia of 6. 3 mmol/L and phosphorus of 7. 0 mg/dL and was started on CVVHD.


More detailed The individual was thoroughly evaluated for an infectious source with radiographic studies and blood and urine cultures, however all work up was negative. Epidermis biopsy was performed which proved diffuse spongiosis, as well as numerous subcorneal pustules filled up with a merged inflammatory infiltrate, predominately consisting of neutrophils, with some associated lymphocytes regular with AGEP.

DIFFERENTIAL Identification If relevant

Other differentials included septic surprise, pustular psoriasis, Toxic epidermal necrolysis, Stevens- Johnson syndrome

TREATMENT If relevant

Erythromycin and Fluconazole were immediately discontinued upon acute decompensation. Due to matter for septic great shock initially, he was began on broad range antibiotics, with Vancomycin, Meropenem and Micafungin. However, when the infectious build up was negative, antibiotics were discontinued. With suspicion of AGEP, he was cured with methylprednisolone 80 mg every 8 time for three days and nights and eventual slow taper on oral steroids.


The patient got designated improvement in both hemodynamics and allergy once began on steroids. He no more required vasopressor providers and was extubated on Day 3 of methylprednisolone. He required four days of CVVHD and experienced complete recovery of both kidney and liver function. He was maintained on oral prednisone with sluggish taper for 14 days.

DISCUSSION Include an extremely brief overview of similar published circumstances

Acute Generalised Exanthematous Pustulosis (AGEP) is a relatively unusual cutaneous condition provoked by drugs- mainly by anti-infective agents, less commonly by microbe infections (3)(4) and sometimes the cause remains unclear. It is thought to be a T-cell mediated neutrophilic irritation and the histological hallmark is a spongiform subcorneal/intraepidermal pustule. The allergy typically begins in the intertriginous area, as seen in our patient, or the facial skin and rapidly spreads to entail all of those other body. Systemic manifestations are usually just limited by include fever and neutrophilic leucocytosis and organ involvement is rare. In a few patients, gentle hepatic and kidney dysfunction has been reported (1)(6)(3). Our circumstance of AGEP was an atypical display with severe systemic engagement resulting in hemodynamic instability and multi-organ dysfunction, in doing so offering an illusion of septic shock. To the best of our knowledge, there have been only a few reported conditions of AGEP with such severe presentation and none of the cases were associated with the use of Erythromycin and Fluconazole (7)(8)(9). In the majority of the severe presentations, Vancomycin was at fault medication (7)(8)(9). It's possible that the combined effect of Erythromycin and Fluconazole that happen to be both hepatically metabolized and alter each other's metabolism resulting in increased drug levels resulted in the drug response being severe with systemic participation as an have an impact on.

Other differentials to consider would be pustular psoriasis, Stevens-Johnson symptoms and Dangerous epidermal necrolysis. The patient had no history of psoriasis and the concern for SJS and TEN was low based on the history, insufficient mucosal involvement and the timing of the drug eruption in a few days of the antibiotics was more in favour of AGEP which was later established by the biopsy results.

Treatment of AGEP entails prompt removal of the offending agent which typically brings about improvement in symptoms in a few days. Topical steroids can be used for symptom alleviation. Systemic steroids are not suggested, but have been found in rare circumstances with severe presentations such as inside our case, but currently there isn't enough data to support the use of systemic steroids to reduce the length of time of the symptoms and early recovery (11)(5)(4)(10).

LEARNING Things/TAKE HOME Information 3 to 5 bullet factors - this is a required field

  • AGEP is a uncommon cutaneous medication eruption which can be severe and imitate septic shock. It ought to be suspected in patients being monitored as septic surprise with negative infectious work up and the patient's condition is constantly on the deteriorate while on anti-infective realtors.
  • Several medications have been known to cause AGEP, but it is unclear concerning which factors donate to its severeness.
  • Discontinuation of at fault agent may not always cause medical improvement, especially in severe cases and there could be a role for systemic steroids to market early clinical restoration.
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